Netta IUCLID

IUCLID dossiers assembled: REACH and biocides.

Netta IUCLID automates IUCLID dossier assembly for REACH registration and biocides authorisation. It parses endpoint study reports, populates IUCLID 6 v9 fields, attaches the study report to each endpoint record, and hands a clean dossier to a scientist for the last-mile review.

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Your study report (PDF)

Study No. KBL-AOT-2611ILLUSTRATIVE STUDY: NOT REAL DATA

FINAL STUDY REPORT

Acute oral toxicity study of NX-417 in Wistar Han rats (acute toxic class method)

Test guideline

The study was performed according to OECD Guideline for the Testing of Chemicals No. 423, Acute Oral Toxicity: Acute Toxic Class Method (adopted 17 December 2001), without deviation.

Statement of GLP compliance

This study was conducted in compliance with the OECD Principles of Good Laboratory Practice (as revised in 1997).

Test system

Species	Rat
Strain	Wistar Han (RccHan:WIST)
Sex	Female, nulliparous and non-pregnant

Route and administration

Route of administration: oral, by gavage. Vehicle: Corn oil (Batch CO-2291), dose volume 10 mL/kg body weight.

Three sequential steps of three females each: 300 mg/kg bw (Step 1), 300 mg/kg bw (Step 2) and 2000 mg/kg bw (Step 3).

Conclusion

The acute oral LD50 cut-off value of NX-417 in female Wistar Han rats is 500 mg/kg body weight. NX-417 meets the criteria for classification as Acute Toxicity Category 4 (H302: Harmful if swallowed).

Kestrel Bioscience Laboratories Ltd (fictional)Illustrative study: not real data

IUCLID 6 endpoint study record

Netta IUCLID 1 min 36 s

ENDPOINT_STUDY_RECORD 7.2.1 Acute toxicity: oral

Materials and methods

Guideline OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method) OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance yes (incl. QA statement) yes (incl. QA statement)

Species rat rat

Strain Wistar Han Wistar Han

Sex female female

Route of administration oral: gavage oral: gavage

Vehicle corn oil corn oil

Doses 300 and 2000 mg/kg bw 300 and 2000 mg/kg bw

Results and discussion

Dose descriptor LD50 cut-off LD50 cut-off

Effect level 500 mg/kg bw 500 mg/kg bw

Applicant’s summary and conclusion

Interpretation of results Category 4 based on GHS criteria Category 4 based on GHS criteria

NX-417_Acute-Oral-Toxicity_OECD423_ILLUSTRATIVE.pdf attached Extracting from study report Ready for .i6z export Download .i6z

NX-417_AcuteToxicityOral.i6zReady to import into IUCLID 6

Whole study report → complete endpoint record

1 min 36 s

Real extraction time·57 values filled, 11 shown here

Illustrative study · actual extraction output

per IUCLID dossier: Weeks → hours
endpoint types covered: 149
two regulations, one tool: REACH · BPR

Regulatory scope

REACH Annex VII–X Registration dossiers
BPR (Biocides) Active substance + product authorisation
IUCLID 6 v9 Current ECHA schema
i6z export Manual upload path
IUCLID server push Direct integration

How it works

From a stack of study PDFs to a validated i6z dossier.

Drop the study PDFs

Upload endpoint study reports (OECD, EPA, in-house) in any language the regulator accepts. We parse the structure, the tables, the summaries and the robust study summaries.
1. Endpoint type
2. Study report for this endpoint
3. Add another endpoint
Endpoints auto-populated

Every relevant IUCLID section and field is filled from the source study. Material, method, results, reliability, key study flag, reference: all extracted and structured for review.
Reviewer in the loop

A scientist reviews each populated endpoint with the original study open alongside. Nothing is finalised without human sign-off.
Validate and export

Built-in IUCLID validation rules run before export. Push directly to your IUCLID 6 v9 server, or export an i6z dossier for manual upload to REACH-IT or R4BP 3.

Input: one study report per endpoint

Netta IUCLIDNew extraction

Netta IUCLID: endpoint cards with study PDFs attached, ready to run

Your study report (PDF)

Study No. KBL-AOT-2611ILLUSTRATIVE STUDY: NOT REAL DATA

FINAL STUDY REPORT

Acute oral toxicity study of NX-417 in Wistar Han rats (acute toxic class method)

Test guideline

The study was performed according to OECD Guideline for the Testing of Chemicals No. 423, Acute Oral Toxicity: Acute Toxic Class Method (adopted 17 December 2001), without deviation.

Statement of GLP compliance

This study was conducted in compliance with the OECD Principles of Good Laboratory Practice (as revised in 1997).

Test system

Species	Rat
Strain	Wistar Han (RccHan:WIST)
Sex	Female, nulliparous and non-pregnant

Route and administration

Route of administration: oral, by gavage. Vehicle: Corn oil (Batch CO-2291), dose volume 10 mL/kg body weight.

Three sequential steps of three females each: 300 mg/kg bw (Step 1), 300 mg/kg bw (Step 2) and 2000 mg/kg bw (Step 3).

Conclusion

The acute oral LD50 cut-off value of NX-417 in female Wistar Han rats is 500 mg/kg body weight. NX-417 meets the criteria for classification as Acute Toxicity Category 4 (H302: Harmful if swallowed).

Kestrel Bioscience Laboratories Ltd (fictional)Illustrative study: not real data

IUCLID 6 endpoint study record

Netta IUCLID 1 min 36 s

ENDPOINT_STUDY_RECORD 7.2.1 Acute toxicity: oral

Materials and methods

Guideline OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method) OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance yes (incl. QA statement) yes (incl. QA statement)

Species rat rat

Strain Wistar Han Wistar Han

Sex female female

Route of administration oral: gavage oral: gavage

Vehicle corn oil corn oil

Doses 300 and 2000 mg/kg bw 300 and 2000 mg/kg bw

Results and discussion

Dose descriptor LD50 cut-off LD50 cut-off

Effect level 500 mg/kg bw 500 mg/kg bw

Applicant’s summary and conclusion

Interpretation of results Category 4 based on GHS criteria Category 4 based on GHS criteria

NX-417_Acute-Oral-Toxicity_OECD423_ILLUSTRATIVE.pdf attached Extracting from study report Ready for .i6z export Download .i6z

NX-417_AcuteToxicityOral.i6zReady to import into IUCLID 6

Whole study report → complete endpoint record

1 min 36 s

Real extraction time·57 values filled, 11 shown here

Illustrative study · actual extraction output

Your study report (PDF)

Study No. KBL-AOT-2611ILLUSTRATIVE STUDY: NOT REAL DATA

FINAL STUDY REPORT

Acute oral toxicity study of NX-417 in Wistar Han rats (acute toxic class method)

Test guideline

The study was performed according to OECD Guideline for the Testing of Chemicals No. 423, Acute Oral Toxicity: Acute Toxic Class Method (adopted 17 December 2001), without deviation.

Statement of GLP compliance

This study was conducted in compliance with the OECD Principles of Good Laboratory Practice (as revised in 1997).

Test system

Species	Rat
Strain	Wistar Han (RccHan:WIST)
Sex	Female, nulliparous and non-pregnant

Route and administration

Route of administration: oral, by gavage. Vehicle: Corn oil (Batch CO-2291), dose volume 10 mL/kg body weight.

Three sequential steps of three females each: 300 mg/kg bw (Step 1), 300 mg/kg bw (Step 2) and 2000 mg/kg bw (Step 3).

Conclusion

The acute oral LD50 cut-off value of NX-417 in female Wistar Han rats is 500 mg/kg body weight. NX-417 meets the criteria for classification as Acute Toxicity Category 4 (H302: Harmful if swallowed).

Kestrel Bioscience Laboratories Ltd (fictional)Illustrative study: not real data

IUCLID 6 endpoint study record

Netta IUCLID 1 min 36 s

ENDPOINT_STUDY_RECORD 7.2.1 Acute toxicity: oral

Materials and methods

Guideline OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method) OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance yes (incl. QA statement) yes (incl. QA statement)

Species rat rat

Strain Wistar Han Wistar Han

Sex female female

Route of administration oral: gavage oral: gavage

Vehicle corn oil corn oil

Doses 300 and 2000 mg/kg bw 300 and 2000 mg/kg bw

Results and discussion

Dose descriptor LD50 cut-off LD50 cut-off

Effect level 500 mg/kg bw 500 mg/kg bw

Applicant’s summary and conclusion

Interpretation of results Category 4 based on GHS criteria Category 4 based on GHS criteria

NX-417_Acute-Oral-Toxicity_OECD423_ILLUSTRATIVE.pdf attached Extracting from study report Ready for .i6z export Download .i6z

Illustrative study · actual extraction output

Your study report (PDF)

Study No. KBL-AOT-2611ILLUSTRATIVE STUDY: NOT REAL DATA

FINAL STUDY REPORT

Acute oral toxicity study of NX-417 in Wistar Han rats (acute toxic class method)

Test guideline

The study was performed according to OECD Guideline for the Testing of Chemicals No. 423, Acute Oral Toxicity: Acute Toxic Class Method (adopted 17 December 2001), without deviation.

Statement of GLP compliance

This study was conducted in compliance with the OECD Principles of Good Laboratory Practice (as revised in 1997).

Test system

Species	Rat
Strain	Wistar Han (RccHan:WIST)
Sex	Female, nulliparous and non-pregnant

Route and administration

Route of administration: oral, by gavage. Vehicle: Corn oil (Batch CO-2291), dose volume 10 mL/kg body weight.

Three sequential steps of three females each: 300 mg/kg bw (Step 1), 300 mg/kg bw (Step 2) and 2000 mg/kg bw (Step 3).

Conclusion

The acute oral LD50 cut-off value of NX-417 in female Wistar Han rats is 500 mg/kg body weight. NX-417 meets the criteria for classification as Acute Toxicity Category 4 (H302: Harmful if swallowed).

Kestrel Bioscience Laboratories Ltd (fictional)Illustrative study: not real data

IUCLID 6 endpoint study record

Netta IUCLID 1 min 36 s

ENDPOINT_STUDY_RECORD 7.2.1 Acute toxicity: oral

Materials and methods

Guideline OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method) OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance yes (incl. QA statement) yes (incl. QA statement)

Species rat rat

Strain Wistar Han Wistar Han

Sex female female

Route of administration oral: gavage oral: gavage

Vehicle corn oil corn oil

Doses 300 and 2000 mg/kg bw 300 and 2000 mg/kg bw

Results and discussion

Dose descriptor LD50 cut-off LD50 cut-off

Effect level 500 mg/kg bw 500 mg/kg bw

Applicant’s summary and conclusion

Interpretation of results Category 4 based on GHS criteria Category 4 based on GHS criteria

NX-417_Acute-Oral-Toxicity_OECD423_ILLUSTRATIVE.pdf attached Extracting from study report Ready for .i6z export Download .i6z

NX-417_AcuteToxicityOral.i6zReady to import into IUCLID 6

Whole study report → complete endpoint record

1 min 36 s

Real extraction time·57 values filled, 11 shown here

Illustrative study · actual extraction output

Endpoint type
Study report for this endpoint
Add another endpoint

The study report is attached to each endpoint record, with a literature reference. No field is invented. Reviewers accept, correct or reject. The tool never signs off on its own work. More consistent than manual review: the system checks every item, every time. No reviewer fatigue, no missed paragraphs.

Endpoints covered

The whole hazard profile, not just the easy bits.

Physical-chemical

Melting / freezing point
Boiling point
Relative density
Vapour pressure
Water solubility
Partition coefficient (log Kow)
Surface tension
Flash point
Auto-ignition
Granulometry

Toxicology

Acute toxicity (oral / dermal / inhalation)
Skin & eye irritation
Skin sensitisation
Genetic toxicity (Ames, MNT, chromosomal)
Repeated-dose toxicity
Reproductive & developmental
Carcinogenicity
Toxicokinetics

Ecotoxicology

Short-term toxicity: fish, daphnia, algae
Long-term toxicity: fish, invertebrates
Sediment organisms
Terrestrial organisms
Activated sludge

Environmental fate

Ready biodegradability
Hydrolysis
Adsorption / desorption
Bioaccumulation
PBT / vPvB assessment

Deployment

Your compliance team picks where the data lives.

Cloud

EU-hosted SaaS

Hosted in the European Union
LLM inference in EU regions under enterprise DPA
Contractual prohibition on training on client data
Onboarding within the week

On-premise

100% air-gapped

Runs entirely inside your network, no outbound calls
Netta custom models, tuned for IUCLID extraction
Your data never leaves your infrastructure
Compatible with hardened, disconnected environments

On-premise deployments run on Netta custom models tuned for IUCLID extraction. Nothing (queries, documents, extracted values) ever leaves your network.

Why Netta IUCLID

Built for the whole dossier, not just one regulation.

REACH and Biocidal Products Regulation, both in one tool
EU-hosted SaaS or fully air-gapped on-premise: your compliance team decides
149 endpoint types across physical-chemical, toxicology, ecotoxicology and environmental fate
No artificial page caps, no per-user metering, no lock-in
Part of the Netta product suite. Combine with Netta Review and Netta Cite for the full dossier workflow

Questions

The ones a reviewer would ask first.

If yours isn’t here, a 30-minute demo is the fastest way to get it answered. We don’t do gated whitepapers.

Book a demo

Which IUCLID version do you support?

IUCLID 6 v9, the current ECHA release. We track schema updates as ECHA publishes them. Dossiers exported from Netta IUCLID validate against the current format checker.

Does it handle biocides (BPR) as well as REACH?

Yes. Netta IUCLID covers REACH Annex VII–X registration dossiers and Biocidal Products Regulation active-substance and product-authorisation dossiers.

Where does the data live?

On the SaaS tier, application and LLM inference run in the European Union under contractual terms prohibiting use of your data for model training. On the on-premise tier, nothing (documents, extracted values, queries) leaves your network.

Can it push directly to an IUCLID 6 server?

Yes. Direct push is supported, and i6z export is always available as a manual path.

What study formats do you accept?

PDF study reports in any language the regulator accepts. OECD test guideline reports, EPA studies, in-house laboratory reports and legacy scans with OCR.

Who does the work: the system or a human?

The system drafts every endpoint from the source studies. A scientist reviews each one and signs off. Nothing is finalised without human approval.

How do you prevent hallucinations in a regulatory context?

Every extracted field is grounded in the original study. The reviewer always has the final say.

How long is onboarding?

Cloud tier: production within the week. On-premise: timeline depends on your infrastructure, typically two to four weeks.

Other products

Get in touch

Ready to see it work on your documents?

Book a 30-minute call. No slides. We run your real documents through the system and you see the output. If it does not save you time, we will tell you.

Book a 30-minute call [email protected]

IUCLID dossiers assembled: REACH and biocides.

From a stack of study PDFs to a validated i6z dossier.

Drop the study PDFs

Endpoints auto-populated

Reviewer in the loop

Validate and export

The whole hazard profile, not just the easy bits.

Physical-chemical

Toxicology

Ecotoxicology

Environmental fate

Your compliance team picks where the data lives.

EU-hosted SaaS

100% air-gapped

Built for the whole dossier, not just one regulation.

The ones a reviewer would ask first.

Netta Review

Netta Cite

Netta Minutes

Netta Inbox

Ready to see it work on your documents?